Can You Plug Vyvanse?

Manish Mishra, MBBS

Medically Reviewed By: Manish Mishra, MBBS


Vyvanse is a stimulant medication that can be inserted into the anus as a form of drug abuse known as “plugging.” However, plugging Vyvanse does not increase feelings of euphoria and can instead cause serious rectal damage.

Lisdexamfetamine dimesylate (brand name Vyvanse) is a stimulant drug used to help those suffering from attention deficit hyperactivity disorder (ADHD). This ADHD medication can also be used to treat those with binge eating disorder.

Despite this, some may participate in Vyvanse abuse, or plugging the drug and inserting it into the rectum. Those who participate in the rectal administration of Vyvanse may suffer from serious, life-threatening side effects.

Vyvanse is a prodrug, meaning it must be digested and metabolized to be activated. Therefore, those who plug Vyvanse will not likely experience the euphoric effects provided by drug abuse.

Plugging Vyvanse 

To plug Vyvanse, a person must crush the tablet or pill. Once in powder form, a person may mix the substance with a liquid. This liquid can be inserted into the rectum.

Vyvanse affects the central nervous system (CNS) by increasing the activity of the neurotransmitters dopamine and serotonin in the brain. This occurs when the drug is orally digested.

If you plug Vyvanse and avoid metabolizing the drug, you will not feel any effects. Although plugging Vyvanse may not create euphoria, this method of administration can cause side effects which may damage the rectum.

Side Effects Of Plugging Vyvanse

When Vyvanse is taken as prescribed, common side effects can occur. However, when the drug is abused, these side effects can be heightened, resulting in more serious and life-threatening effects.

Common Side Effects

The U.S. Food and Drug Administration (FDA) states common side effects of Vyvanse can include:

  • dry mouth
  • weight loss
  • constipation
  • dizziness
  • nausea
  • sleepiness

Rectal Damage

Damage to the rectum may take place when a person plugs Vyvanse. For instance, those plugging Vyvanse may experience:

  • damage to the rectal membranes
  • bleeding of the rectum
  • frequent infections
  • irritation of the anus
  • difficulty with bowel movements

Those who share syringes or other drug paraphernalia may develop bacteria infections. HIV or hepatitis c may possibly be transmitted from one person to another if any bodily fluids are exchanged.

Dangers Of Vyvanse Abuse

Plugging Vyvanse may create certain dangers to your health, especially if the drug is combined with other substances or consumed in high doses.

Drug Interactions

Combining medications with Vyvanse can create adverse effects. Some of the substances to avoid while taking this stimulant include:

  • supplements
  • opioids
  • over-the-counter painkillers
  • certain prescription drugs
  • methamphetamine
  • certain antidepressants including Wellbutrin and Prozac

Additionally, Vyvanse should not be combined with other ADHD medications such as:

  • methylphenidate (Ritalin)
  • amphetamine and dextroamphetamine (Adderall)
  • Concerta
  • Dexedrine
  • Adderall XR

Vyvanse Overdose

Symptoms of a Vyvanse overdose may include:

  • heart problems, including a possible heart attack
  • respiratory depression
  • high blood pressure
  • seizures
  • hallucinations
  • confusion
  • feelings of panic

Contact 911 immediately if an overdose is suspected.

Vyvanse Addiction Treatment

Plugging, snorting, injecting, or smoking Vyvanse are all forms of substance abuse. Thankfully, Ohio Recovery Center can help.

At our treatment center, we provide a wide-range of inpatient treatment options. Our evidence-based approach provides you with a personalized treatment plan that may include medical detox, behavioral therapy, peer support, and mental health services.

To learn more about our treatment program, please contact us today.

  1. Clinical Drug Investigation
  2. Drug Enforcement Administration
  3. Food and Drug Administration
  4. National Library of Medicine: MedlinePlus
  5. Pharmacy and Therapeutics

Written by Ohio Recovery Center Editorial Team

© 2024 Ohio Recovery Center | All Rights Reserved

* This page does not provide medical advice.

Prefer Texting?
We've got you covered.

Receive 24/7 text support right away.
There is no obligation and you can opt out at any time.

Sign up for text support

Receive 24/7 text support right away.
There is no obligation and you can opt out at any time.
Let us walk you through the treatment process. We're here to help.
For 24/7 Treatment Help:
100% Free & Confidential. Call (419) 904-4158