How Long Does Vyvanse Stay In Your System?

Manish Mishra, MBBS

Medically Reviewed By: Manish Mishra, MBBS

on August 21, 2023

The prescription stimulant Vyvanse stays in a person’s system for at least 2-3 days after last use. However, the drug has various detection windows depending on the drug test performed and may be detected in urine for about 3 days and hair follicles for up to 90 days.

The prescription stimulant medication Vyvanse (the brand name for lisdexamfetamine dimesylate) can stay in a person’s system for at least 60 hours or within 3 days after use. 

Vyvanse is used to help treat attention deficit hyperactivity disorder (ADHD) and those suffering from binge eating disorder.

This drug is a Schedule II controlled substance according to the United States Drug Enforcement Administration (DEA), meaning it has a high potential for abuse. 

Vyvanse may show on a drug test if you’re required to take one for legal or employment reasons.

The Half-Life Of Vyvanse

The half-life of Vyvanse is 12 hours which means the drug may be removed from your body in a little over 60 hours or within 3 days from the last dose of Vyvanse taken. 

However, depending on the type of drug test a person must perform, there are different detection times for the last use of the stimulant.

Types Of Vyvanse Drug Screens

Because this central nervous system stimulant drug is considered a controlled substance, there may be necessary reasons for a drug test to take place. Whether needed for legal reasons or asked by your doctor, the type of drug screening may differ.

Vyvanse Urine Tests

With a urine test, Vyvanse can be found in the system for 3-5 days. This may be the most common form of drug test performed. Once a sample is given, it will be taken to a lab to discover if traces of the drug are detected in your system.

Vyvanse Saliva Tests

As one of the more simple tests, a saliva test may be used to determine if Vyvanse has been used during the last 5-48 hours. The oral fluid on a mouth swab will be tested.

Vyvanse Blood Tests

A blood test can have the shortest detection window of up to 8 hours. With a blood test, a medical professional will use a needle to draw blood. This is a relatively fast test and detects the drug in a manner of only minutes or hours after the last dose.

Vyvanse Hair Tests

If a hair test is required, the detection window may be the longest, with the drug lasting for a month or 3 months

Typically, a hair test will involve providing a hair sample. From there, a healthcare worker will take the hair follicle to determine if there are any traces of metabolites associated with Vyvanse.

Side Effects Of Vyvanse

How long Vyvanse stays in a person’s system may also depend on the amount of the drug taken. Those who abuse Vyvanse may have a substantial amount of the drug in their system which can lead to serious side effects, including a potential Vyvanse overdose

According to the United States Food and Drug Administration (FDA), a range of side effects can also occur when Vyvanse abuse takes place, including:

  • severe weight loss
  • cardiovascular problems
  • withdrawal symptoms
  • mental health problems such as anxiety or depression
  • serotonin syndrome
  • Vyvanse addiction

Drug Interactions

Because Vyvanse is a strong stimulant, drug addiction may take place, leading a person to combine medication or substances to achieve a high. Even when taken as prescribed, certain medications should be avoided with Vyvanse.

Substances to avoid while taking Vyvanse include:

  • other stimulants such as Adderall or Ritalin
  • antidepressants such as monoamine oxidase inhibitors (MAOIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), and selective serotonin reuptake inhibitors (SSRIs)
  • alcohol
  • benzodiazepines
  • opioids
  • illicit drugs
  • supplements

Combining any of these substances with Vyvanse is a form of substance abuse.

Vyvanse Addiction Treatment 

For those of you seeking treatment options for prescription drug abuse, consider Ohio Recovery Center. We provide detox, inpatient care, and evidence-based practices like behavioral therapy, mental health counseling, and peer support groups.

To learn more about our treatment programs, please contact us today.

  1. Child and Adolescent Psychiatric Clinics of North America
  2. Food and Drug Administration
  3. National Institute on Drug Abuse
  4. National Library of Medicine: MedlinePlus
  5. Pharmacy and Therapeutics
  6. Springer: Clinical Drug Investigation

Written by Ohio Recovery Center Editorial Team

© 2024 Ohio Recovery Center | All Rights Reserved

* This page does not provide medical advice.

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