Can You Smoke Vyvanse?

Manish Mishra, MBBS

Medically Reviewed By: Manish Mishra, MBBS


Although this medication can be crushed and smoked, smoking Vyvanse does not produce a “high” because it is a prodrug that must be metabolized before taking effect.

Although Vyvanse (the brand name for lisdexamfetamine dimesylate), is a medication used to treat symptoms associated with attention deficit hyperactivity disorder (ADHD), it is a stimulant drug that can be smoked. 

However, smoking Vyvanse does not cause a person to experience any desired effects, including feelings of euphoria.

Despite this, smoking Vyvanse can still be harmful for your lung health. According to the United States Drug Enforcement Administration (DEA), Vyvanse is a Schedule II controlled substance with potential for abuse and psychological or physical dependence.

Smoking Vyvanse can lead to serious health problems and is considered a form of drug abuse.

Smoking Vyvanse

Vyvanse is a prodrug, which means it is only activated when digested. However, those wishing to smoke the stimulant medication may empty the contents of the drug capsules.

The contents can then be poured into a pipe, sprinkled on other smokable drugs such as marijuana, or simply rolled into paper and smoked in that manner.

Why Smoking Vyvanse Isn’t Effective

Vyvanse works by interacting with certain neurotransmitters in the brain, increasing the levels of dopamine and norepinephrine. While taking Vyvanse in high doses may lead to mild euphoria, smoking the drug does not increase its effects as the drug must be metabolized to work.

Vyvanse is not only used to treat symptoms of ADHD, but also helps treat those suffering from binge eating disorder as well. This ADHD medication is a central nervous system stimulant (CNS) that can lead to severe side effects when abused.

Side Effects Of Vyvanse

Vyvanse can create various side effects when taken as prescribed. When abused, however, more severe dangers can take place.

Common Side Effects

According to the United States Food and Drug Administration (FDA), some of the common side effects of Vyvanse can include:

  • diarrhea
  • dizziness
  • anxiety
  • dry mouth
  • constipation
  • irritability
  • vomiting
  • loss of appetite
  • weight loss

Serious Side Effects

When substance abuse takes place, more serious side effects may occur, including:

  • cardiovascular problems including hypertension
  • respiratory issues
  • mental health issues
  • Vyvanse dependence and withdrawal

Vyvanse Withdrawal Symptoms

When Vyvanse use abruptly stops, withdrawal symptoms can occur. Some of the withdrawal symptoms of Vyvanse may include:

  • fatigue
  • mood swings
  • depression
  • increased appetite
  • headaches
  • tremors
  • sweating
  • cravings for the drug

Speak with your healthcare provider before immediately stopping your medication “cold turkey.”

Dangers Of Smoking Vyvanse

There may be serious health repercussions for those who participate in Vyvanse drug use via smoking or other unapproved methods of abuse.

Lung Health

Respiratory issues may take place when Vyvanse is continually abused from inhalation. Damage to the lungs can occur due to the harshness of the drug.

The lungs can become irritated and those suffering from asthma or other breathing problems may experience greater irritation, leading to wheezing or coughing.

Drug Interactions

Those who take Vyvanse should avoid combining the drug with other substances, as drug interactions may take place. Substances to avoid while taking Vyvanse include:

  • alcohol
  • benzodiazepines
  • opioids
  • other stimulant prescription drugs such as methylphenidate (Ritalin, Concerta) and dextroamphetamine (Adderall)
  • drugs containing methamphetamine and amphetamine
  • antidepressant such as monoamine oxidase inhibitors (MAOIs)

Vyvanse Overdose

Those who take Vyvanse in high doses may experience a life-threatening overdose. Some of the symptoms of a Vyvanse overdose can include:

  • fluctuations in blood pressure and heart rate
  • confusion
  • respiratory depression
  • cardiovascular events or hypertension
  • hallucinations or a form of psychosis
  • seizures
  • coma

Vyvanse Addiction Treatment

If you or a loved one are struggling with prescription drug abuse, Ohio Recovery Center can help. 

At our treatment center, we offer a range of evidence-based practices including behavioral therapy, medical detox, group therapy, and other inpatient treatment options. To learn more about our services, please contact our helpline today.

  1. Clinical Drug Investigation
  2. Drug Enforcement Administration
  3. Food and Drug Administration
  4. National Institute on Drug Abuse
  5. National Library of Medicine: MedlinePlus
  6. Pharmacy and Therapeutics

Written by Ohio Recovery Center Editorial Team

© 2024 Ohio Recovery Center | All Rights Reserved

* This page does not provide medical advice.

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