Percocet Vs. Norco | Differences & Similarities
Percocet and Norco share many similarities including drug class, side effects, drug interactions, and how they work—they differ in terms of ingredients and dosage.
Although the two drugs have a lot of similarities, they are distinct and different.
While both drugs are helpful and approved for pain relief, they’re both habit-forming and can lead to dependence and addiction.
Differences Between Percocet & Norco
While there are not a lot of differences between Percocet and Norco, they are two separate drugs. One can work for one person and not work for another.
The major difference between Percocet and Norco is what they contain. While they’re both combination drugs, they contain different ingredients.
Percocet and Norco also differ in the typical dosage usually prescribed. For Norco, it’s recommended to take a dose every four to six hours as needed. For Percocet, it’s recommended you take a dose every six hours as needed.
Similarities Between Percocet & Norco
Norco and Percocet are very similar drugs. Because they are part of the same opioid drug class and both used for pain management, they also happen to share many other aspects including side effects, classification, and drug interactions.
The most common side effects of Percocet and Norco are very similar and can include:
- stomach pain
- dry mouth
- impaired motor skills
Percocet and Norco are part of the same drug class. They are both opioid analgesics or narcotic analgesics. This means they both contain opioids and work to relieve moderate to severe pain.
Percocet and Norco are part of the same drug schedule too. The FDA and DEA classify both pain medications as Schedule II controlled substances. This means they have a high potential for abuse and can lead to physical dependence, withdrawal symptoms, and addiction.
Other drugs in this schedule include codeine, hydrocodone, morphine, and oxycodone.
How They Work
Norco and Percocet also work in similar ways. They both bind to the opioid receptors in the central nervous system and disrupt pain signals from the brain to the rest of the body. This is how they treat acute and chronic pain.
There are also several drugs that Norco and Percocet don’t mix well with. When they are mixed, the combination can lead to serious adverse reactions. Some of the drugs that should not be mixed with either prescription medication include:
- inhibitors of CYP3A4 and CYP2D6
- over-the-counter supplements
- other CNS depressants
- other opioid medications
- selective serotonin reuptake inhibitors (SSRIs)
- serotonin and norepinephrine reuptake inhibitors (SNRIs)
- tricyclic antidepressants
- monoamine oxidase Inhibitors (MAOIs)
- muscle relaxants
Percocet also doesn’t mix well with beta-blockers and oral contraceptives.
Percocet and Norco have similar contraindications or health issues that the pain relievers can actually make worse. If you have any of the following medical conditions, Percocet and/or Norco is likely not right for you:
- respiratory depression
- acute or severe bronchial asthma
- paralytic ileus
Percocet should also not be taken if you have a hypersensitivity to oxycodone and Norco should not be taken if you have a hypersensitivity to hydrocodone
These two opioid prescription drugs also have the same half-life. A half-life is the amount of time it takes for half a dose of the drug to leave your system. For Percocet and Norco, their half-life is about 4 hours.
Signs Of Overdose
When someone overdoses on Norco or Percocet, the signs and symptoms of an overdose are very similar. Some of the overdose symptoms they share may include:
- bluish lips or skin
- cold, clammy skin
- extreme sleepiness
- general feelings of discomfort
- loss of consciousness
- low blood pressure
- irregular heartbeat
- slow breathing
If you or a loved one experience any of these signs and symptoms, call 911 immediately. An opioid overdose can easily be life-threatening if left untreated.
In Ohio, there were over 400 unintentional opioid overdose deaths in 2020 alone.
If you or a loved one is struggling with opiate/opioid abuse and looking for addiction treatment in Ohio, Ohio Recovery Center is here for you. Contact us today for information on our inpatient treatment options.
- National Library of Medicine: MedlinePlus — Hydrocodone Combination Products https://medlineplus.gov/druginfo/meds/a601006.html
- National Library of Medicine: MedlinePlus — Oxycodone https://medlineplus.gov/druginfo/meds/a682132.html
- Food and Drug Administration (FDA) — Norco https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/040099s023lbl.pdf
- Food and Drug Administration (FDA) — Percocet https://www.accessdata.fda.gov/drugsatfda_docs/label/2006/040330s015,040341s013,040434s003lbl.pdf