Hydrocodone Side Effects | Hydrocodone/Acetaminophen Warnings

Manish Mishra, MBBS

Medically Reviewed By: Manish Mishra, MBBS

on December 6, 2022

Common side effects of hydrocodone may include dry mouth, drowsiness, constipation, sedation, and nausea. Serious side effects of hydrocodone may include breathing problems, low blood pressure, a loss of appetite, and chest pain.

Hydrocodone is an opioid analgesic that can treat chronic pain and severe pain. It is sold under the brand name Hysingla or as a combination product with acetaminophen (Vicodin, Norco, Lortab).

Hydrocodone can be habit-forming, and the effectiveness of the drug may be outweighed by its negative effects over time. Consult your doctor if you experience negative side effects or have difficulty stopping hydrocodone.

Side Effects Of Hydrocodone

Common side effects of hydrocodone may include:

  • tiredness
  • sleepiness
  • nausea
  • vomiting
  • impairment
  • sedation
  • sore throat
  • lightheadedness

These effects may occur during any instance of hydrocodone use.

Warnings For Hydrocodone Use

Official warnings for hydrocodone labels suggest consulting with your healthcare provider before beginning an opioid medication. Informing your doctor about your medical history can also help you determine the safety of opioid pain relievers.

Drug Interactions

Certain over-the-counter and prescription drugs can interact with hydrocodone in the body. Hydrocodone can create additive sedative effects with benzodiazepines, muscle relaxants, antihistamines, or alcohol.

When combined, these effects can become stronger compared to taking each substance individually. The additive effects can cause a previously safe dose to be dangerous.

Drug Overdose

An opioid overdose can occur when high doses of hydrocodone are ingested at once, or if hydrocodone is mixed with other drugs with depressant properties. A hydrocodone overdose can cause breathing problems, unconsciousness, and death.

An acetaminophen overdose may occur when taking combination products. Acetaminophen overdose can result in liver damage, and can also be life-threatening.

Allergic Reactions & Other Adverse Effects

An allergic reaction to hydrocodone may cause:

  • skin rash
  • hives
  • dizziness
  • shallow breathing

Patients with preexisting health conditions such as kidney disease, liver problems, or trouble urinating may experience adverse effects in these areas while taking hydrocodone.

Patients who are pregnant or breastfeeding may wish to inform a healthcare professional. Opioids can collect in breast milk and be transferred to a nursing infant, which can be dangerous to their health.

Risk Of Substance Use Disorder

Hydrocodone is a Schedule II controlled substance in the United States. Its potential for drug abuse and addiction is recognized by health organizations.

Taking hydrocodone for long periods of time can result in physical dependence, withdrawal symptoms when trying to quit, and decreased mental health. These effects can be indicative of a substance use disorder, which can be difficult to overcome without professional help.

If you or a loved one are struggling with serious side effects caused by hydrocodone use, contact Ohio Recovery Center. Our inpatient opioid addiction treatment programs can offer professional assistance and a safe environment for recovery.

  1. Food and Drug Administration — Vicodin Drug Label https://www.accessdata.fda.gov/drugsatfda_docs/label/2006/088058s027lbl.pdf
  2. National Library of Medicine: MedlinePlus — Hydrocodone https://medlineplus.gov/druginfo/meds/a614045.html
  3. National Library of Medicine: MedlinePlus — Hydrocodone Combination Products https://medlineplus.gov/druginfo/meds/a601006.html

Written by Ohio Recovery Center Editorial Team

© 2024 Ohio Recovery Center | All Rights Reserved

* This page does not provide medical advice.

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